Smaller format lenses are limited in their close-focus ability, because focus is achieved by a built-in helix which gives a fixed range. Large format lenses have no helix so that, as Joanna says, focus (both near and far) is limited by the bellows extension alone. As a mental exercise, you might imagine mounting the lens at one end of a drainpipe and the film at the other. Huge magnification but impractical. It’s possible that aberrations may degrade the image in extreme cases as designers must make assumptions about the most likely uses of the lens and optimise for that.
A major problem with close focus is that increasing the bellows extension to focus more closely will move the lens closer to the subject, thus changing the point of focus, which in turn means the lens must be moved to re-focus, which in turn moves the point of focus...
There are two ways around this. Firstly, use the rear standard only to focus, keeping the lens-to subject distance unchanged. Obviously, this depends on the construction of the camera. The second way is to decide on the magnification you want, calculate the extension required and move the whole camera back and forth to focus. The two methods can be used together, unless you need to achieve a very specific magnification.
Another difficulty is that with such a long lens, depth of field will be exceptionally small. I’m guessing that you will already know that.
This is one of the cases where a modern DSLR, using focus stacking, may be the weapon of choice.